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Background To assess the long-term efficacy and the pattern of failure of concurrent chemoradiotherapy followed by high dose rate (HDR) brachytherapy for stage T2-3 N0-1 M0 esophageal carcinoma. Methods Forty-six patients with clinical stage T2-3 N0-1 M0 esophageal cancer received concurrent chemoradiotherapy followed by HDR brachytherapy. The chemotherapy regimen was a combination of cisplatin...
We herein report a patient demonstrating esophageal carcinoma with humoral hypercalcemia and leukocytosis. A 56-year-old Japanese man complained of a 2-month history of pyrexia. The radiological and endoscopic findings showed advanced esophageal carcinoma with a giant intraabdominal lymph node metastasis. Preoperative examination suggested that the tumor, consisting of squamous cell carcinoma, produced...
Background In esophageal carcinoma, the clinical significance of immunohistochemically (IHC)-detected lymph node (LN) micrometastasis is still controversial. We designed this multicenter study to determine the clinical significance of IHC-detected LN micrometastasis in esophageal carcinoma. Methods The subjects were 164 patients with histopathologically confirmed LN-negative esophageal carcinoma...
Although intraarterial steroid infusion therapy has previously been shown to be effective for inflammatory bowel disease, it has not yet been applied for the treatment of hemorrhagic radiation gastritis. We report herein a case of hemorrhagic radiation gastritis of gastric tube that occurred after chemoradiation therapy for postoperative peritoneal lymph node metastasis in a patient with esophageal...
Background Thoracoabdominal esophagectomy with three-field lymphadenectomy is considered one of the best treatments for thoracic esophageal carcinoma because the disease is aggressive and lymph node metastasis is common. However, the efficacy of the procedure remains unclear, and it is associated with high postoperative mortality and morbidity. Methods Seventy patients with esophageal carcinoma...
Undifferentiated carcinoma of the esophagus (UEC) is an uncommon esophageal malignancy, and patients with UEC have an especially poor prognosis because of extensive metastasis even at an early stage. A standard treatment regimen for UEC has not yet been established. We have experienced a case with UEC (T2N1, stage II) that achieved complete remission by chemoradiotherapy [cisplatin (CDDP) + 5-fluorouracil...
A 64-year-old man presented with dysphagia and heartburn. Upper gastrointestinal endoscopy showed an irregular type 2 tumor of the lower esophagus. Histological examination of the biopsy specimen revealed undifferentiated carcinoma, small cell type. Subtotal esophagectomy was performed. Two months after the initial surgery, an intradural extramedullary metastasis was found, and tumorectomy was performed...
A 57-year-old man, who had been diagnosed as having flask type, grade II achalasia of the esophagus at the age of 26, underwent Heller’s esophagomyectomy in a nearby hospital in 1971. A type 0-Is lesion measuring 2 cm in size was found on the middle thoracic esophagus in September 2002. A protruding tumor with a central depression, not stained with iodine, was detected by endoscopic examination. Standard...
In an attempt to improve survival of patients with locally advanced esophageal cancer, chemoradiotherapy consisting of cisplatin, 5-fluorouracil (5-FU), and irradiation has recently been used. For such patients, concurrent chemoradiotherapy using docetaxel in combination with cisplatin and 5-FU has been introduced and is under evaluation. We herein report an esophageal cancer patient with concomitant...
We present herein a case of a patient who was clinically diagnosed as having a granulocyte-colony stimulating factor (G-CSF)-producing tumor on the basis of the close correlation of the hematological parameters with the tumor status and his high serum G-CSF level. A 76-year-old male patient underwent transthoracic radical esophagectomy for advanced carcinoma of the lower esophagus. His leukocyte count...
Background This study was designed to conduct a retrospective analysis of late toxicity following chemoradiotherapy (CRT) for esophageal carcinoma. Methods The 49 first-onset esophageal carcinoma cases who allowed evaluation of late toxicity were the subjects. The incidence, severity, and background factors were analyzed for late toxicity (pneumonitis, pleural effusion, pericardial effusion). Performance...
Background Although the feasibility and advantages of video-assisted thoracoscopic esophagectomy (VATS-E) for esophageal cancer are well studied, its application is limited, possibly because it is technically complex. Methods Ninety-eight patients who underwent VATS-E at our institutes were divided into three groups by the type of thoracoscope, TV monitor, and patient position used. For the first...
Polymyositis is known to amalgamate with malignant tumor. Here, we report a case of successfully resected esophageal carcinoma that amalgamated with polymyositis. Moreover, this is a rare case of squamous cell carcinoma combined with Barrett’s adenocarcinoma. A 47-year-old man was admitted to a hospital because of progressive dysphagia and difficulty in walking. Laboratory data showed creatine phosphokinase...
Diaphragmatic herniation after esophagectomy for carcinoma of the esophagus is a rare but preventable postoperative complication. For patients with symptoms, surgical repair of the hernia is recommended to prevent the potentially disastrous complications. In patients with asymptomatic hernias, a watchful waiting approach is reasonable. To prevent diaphragmatic herniation, we emphasize the importance...
A novel method of endoscopic submucosal dissection (ESD) has improved en bloc resection rates and decreased local recurrence after endoscopic therapy as compared with endoscopic mucosal resection (EMR), and resected ESD specimens allow accurate histopathological assessment. Although ESD has become popular for treating gastric neoplasms, esophageal ESD is more difficult than gastric ESD because of...
Background Endoscopic resection was recommended as treatment for mucosal epithelium or lamina propria mucosae lesions not exceeding two-thirds of the circumference. The aim of this study was to verify the outcomes of endoscopic resection and surgery for early and superficial carcinoma of the esophagus. Methods Endoscopic submucosal dissection (ESD) was performed for 56 cases of early and superficial...
Background and objective Monitoring of central venous blood oxygen saturation (ScvO2) has recently become easier and safer to perform, but its clinical usefulness following esophagectomy has yet to be established. This study evaluated the use of continuous monitoring of ScvO2 in this setting, focusing on its relationship with hemoglobin (Hb) concentrations, and reconsideration about an appropriate...
Basaloid squamous carcinoma (BSC) of the esophagus is a rare but distinct variant of esophageal carcinoma, identical to BSC of the upper aerodigestive tract. The incidence of BSC has been reported to present 0.4–3.6% of total esophageal malignant tumors. The average age of BSC patients was 64 years, ranging from 42 to 87 years, with male predominance (male to female ratio 6.8:1). The tumor preferentially...
Esophageal squamous cell carcinoma (SCC) is frequently associated with a high mortality rate as a result of late diagnosis and/or aggressive behavior. Although multimodal treatment is applied for advanced tumors, many patients suffer from progressive disease and rapid recurrence. Besides various imaging techniques, serum biomarkers should also be useful for early diagnosing and treatment monitoring...
We report a case of therapy-related acute myeloid leukemia (t-AML), which developed following chemotherapy involving cisplatin and 5-fluorouracil for esophageal carcinoma. A 70-year-old man with past history of esophageal carcinoma, which was treated with subtotal esophagectomy 32 months earlier followed by 2 courses of chemotherapy involving cisplatin and 5-fluorouracil, was diagnosed with t-AML...
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